4hbe | pdb_00004hbe

Crystal Structure of Rubella virus capsid protein (residues 127-277)

spinqualitylabelsall models 4hbe, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hbe is a 2 chain structure with sequence from Rubv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4har, 4hbo Gene: Capsid (RUBV) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Rubella virus (RV) is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, RV infection leads to severe damage in fetuses. Despite its medical importance, compared with the related alphaviruses, very little is known about the structure of RV. The RV capsid protein is an essential structural component of virions as well as a key factor in virus-host interactions. Here we describe three crystal structures of the structural domain of the RV capsid protein. The polypeptide fold of the RV capsid protomer has not been observed previously. Combining the atomic structure of the RV capsid protein with the cryoelectron tomograms of RV particles established a low-resolution structure of the virion. Mutational studies based on this structure confirmed the role of amino acid residues in the capsid that function in the assembly of infectious virions. Rubella virus capsid protein structure and its role in virus assembly and infection.,Mangala Prasad V, Willows SD, Fokine A, Battisti AJ, Sun S, Plevka P, Hobman TC, Rossmann MG Proc Natl Acad Sci U S A. 2013 Nov 26. PMID:24282305 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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