3ki4 | pdb_00003ki4

Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-P

spinqualitylabelsall models 3ki4, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ki4 is a 1 chain structure with sequence from "bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: G9P, GOL Related: 3ess, 2q6m, 2q5t, 3ki0, 3ki1, 3ki2, 3ki3, 3ki5, 3ki6, 3ki7 Gene: chxa, toxA ("Bacillo virgola del Koch" Trevisan 1884) Activity: NAD(+)--diphthamide ADP-ribosyltransferase, with EC number 2.4.2.36 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae. See Also Exotoxin

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