3uyj | pdb_00003uyj

Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG

spinqualitylabelsall models 3uyj, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3uyj is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AKG, NI Gene: JMJD5, KDM8 (HUMAN) Activity: [Histone_H3-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number 1.14.11.27 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. See Also Jumonji domain-containing protein

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