3v3k | pdb_00003v3k

Human caspase 9 in complex with bacterial effector protein

spinqualitylabelsall models 3v3k, resolution 3.49Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3v3k is a 16 chain structure with sequence from Eco57 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: CASP9, MCH6 (HUMAN), ECs1815, Z6020 (ECO57) Activity: Caspase-9, with EC number 3.4.22.62 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. [NLEF_ECO57] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells. See Also Caspase

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