4or8 | pdb_00004or8

Crystal structure of Marburg virus VP24

spinqualitylabelsall models 4or8, resolution 2.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4or8 is a 2 chain structure with sequence from Lake victoria marburgvirus (strain musoke-80). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: VP24 (Lake Victoria marburgvirus (strain Musoke-80)) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [VP24_MABVM] May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. Publication Abstract from PubMed The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting beta-shelf and an alternate conformation of the N-terminal polypeptide. Crystal Structure of Marburg Virus VP24.,Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO J Virol. 2014 May;88(10):5859-63. doi: 10.1128/JVI.03565-13. Epub 2014 Feb 26. PMID:24574400 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also VP24

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