3o4r | pdb_00003o4r

Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)

spinqualitylabelsall models 3o4r, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3o4r is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, EPE, GOL, NAP Related: 2zat Gene: DHRS4, UNQ851/PRO1800 (HUMAN) Activity: Carbonyl reductase (NADPH), with EC number 1.1.1.184 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [DHRS4_HUMAN] Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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