4me3 | pdb_00004me3

1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM

spinqualitylabelsall models 4me3, resolution 1.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4me3 is a 1 chain structure with sequence from "thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Gene: Ta0799 ("Thermoplasma acidophila" (sic) Darland et al. 1970) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-A crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25A of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication. The 1.8-A Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament.,Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS J Mol Biol. 2013 Dec 27. pii: S0022-2836(13)00812-7. doi:, 10.1016/j.jmb.2013.12.025. PMID:24378617 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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