3hwn | pdb_00003hwn

CATHEPSIN L with AZ13010160

spinqualitylabelsall models 3hwn, resolution 2.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3hwn is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BD3 Gene: CTSL1, CTSL (HUMAN) Activity: Cathepsin L, with EC number 3.4.22.15 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors. Design of selective Cathepsin inhibitors.,Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. Epub 2009 Jun 27. PMID:19616430 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cathepsin

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