3plt | pdb_00003plt

Crystal structure of Lsp1 from Saccharomyces cerevisiae

spinqualitylabelsall models 3plt, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3plt is a 3 chain structure with sequence from Atcc 18824. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3kq1 Gene: LSP1, YPL004C (ATCC 18824) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LSP1_YEAST] Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. Publication Abstract from PubMed Plasma membranes are organized into domains of different protein and lipid composition. Eisosomes are key complexes for yeast plasma membrane organization, containing primarily Pil1 and Lsp1. Here we show that both proteins consist mostly of a banana-shaped BAR domain common to membrane sculpting proteins, most similar to the ones of amphiphysin, arfaptin 2 and endophilin 2. Our data reveal a previously unrecognized family of BAR-domain proteins involved in plasma membrane organization. Eisosome-driven plasma membrane organization is mediated by BAR domains.,Ziolkowska NE, Karotki L, Rehman M, Huiskonen JT, Walther TC Nat Struct Mol Biol. 2011 Jun 19. doi: 10.1038/nsmb.2080. PMID:21685922 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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