Retinol-binding protein

Function

Retinol-binding protein (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. Plasma RBP (PRBP) carries retinol in blood while cellular RBP (CRBP) carries retinol in the cell.

Relevance

RBP is used to assess vitamin A deficiency as it binds 1:1 to retinol.

3D structures of retinol-binding protein

Updated on 08-August-2016

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• Plasma retinol-binding protein (PRBP)
  • 1rbp, 1jyd, 1brp, 1brq - hRBP – human
    
  • 1jyj - hRBP (mutant)
    
  • 1aqb - RBP – pig
    
  • 1hbq – bRBP – bovine
    
• Plasma RBP complex
  • 3bsz - hRBP II + transthyretin + antibody + retinol
    
  • 3fmz - hRBP IV + non-retinoid ligand
    
  • 2wq9 - hRBP IV + oleate
    
  • 2wq9 - hRBP IV + linoleate
    
  • 2wqa - hRBP IV + transthyretin + oleate
    
  • 1iiu - RBP + retinol – chicken
    
  • 1rlb - cRBP + transthyretin
    
  • 1kt3, 1kt4, 1kt5, 1kt6, 1kt7, 1hbp - RBP + retinol
    
  • 1erb, 1fel, 1fem, 1fen - bRBP + retinol derivative
    
  • 1qab - rRBP + transthyretin
    
• Cellular RBP (CRBP)
  • 1jbh, 1kgl, 1mx7 - rRBP I – rat - NMR
    
  • 1b4m - rRBP II – NMR
    
  • 1opa – rRBP II
    
  • 2rcq - hRBP II
    
  • 1ggl - hRBP III
    
  • 1lpj - hRBP IV
    
  • 1kqx – ZeRBP – zebrafish
• Cellular RBP complex
  • 1mx8 - rRBP I + retinol – NMR
    
  • 1eii - rRBP II + retinol – NMR
    
  • 2rct - hRBP II + retinol
    
  • 1kqw - ZeRBP + retinol
    
  • 1crb, 1opb - rRBP + retinol
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman