4ijj | pdb_00004ijj

Structure of transcription factor DksA2 from Pseudomonas aeruginosa

spinqualitylabelsall models 4ijj, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ijj is a 3 chain structure with sequence from Pseab. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Gene: PA14_73020 (PSEAB) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Transcription factor DksA contains a four-Cys Zn(2 +)-finger motif thought to be responsible for structural integrity and the relative disposition of its domains. Pseudomonas aeruginosa encodes an additional DksA paralog (DksA2) that is expressed selectively under Zn(2+) limitation. Although DksA2 does not bind Zn(2+), it complements the Escherichia coli dksA deletion and has similar effects on transcription in vitro. In this study, structural and biochemical analyses reveal that DksA2 has a similar fold, domain structure and RNA polymerase binding properties to those of the E. coli DksA despite the lack of the stabilizing metal ion. Structured summary of protein interactions: RNAPandDksA2bindbybiochemical(View interaction) DksAandRNAPbindbybiochemical(View interaction) DksA2andDksA2bindbyX-ray crystallography(View interaction). DksA2, a zinc-independent structural analog of the transcription factor DksA.,Furman R, Biswas T, Danhart EM, Foster MP, Tsodikov OV, Artsimovitch I FEBS Lett. 2013 Feb 14. pii: S0014-5793(13)00123-3. doi:, 10.1016/j.febslet.2013.01.073. PMID:23416301 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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