3tc2 | pdb_00003tc2

Crystal structure of potato serine protease inhibitor.

spinqualitylabelsall models 3tc2, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3tc2 is a 3 chain structure with sequence from Solanum tuberosum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Potato serine protease inhibitor (PSPI) constitutes about 22% of the total amount of proteins in potato tubers (cv. Elkana), making it the most abundant protease inhibitor in the plant. PSPI is a heterodimeric double-headed Kunitz-type serine protease inhibitor that can tightly and simultaneously bind two serine proteases by mimicking the substrate of the enzyme with its reactive-site loops. Here, the crystal structure of PSPI is reported, representing the first heterodimeric double-headed Kunitz-type serine protease inhibitor structure to be determined. PSPI has a beta-trefoil fold and, based on the structure, two reactive-site loops bearing residues Phe75 and Lys95 were identified. Structure of a post-translationally processed heterodimeric double-headed Kunitz-type serine protease inhibitor from potato.,Meulenbroek EM, Thomassen EA, Pouvreau L, Abrahams JP, Gruppen H, Pannu NS Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):794-9. doi:, 10.1107/S090744491201222X. Epub 2012 Jun 15. PMID:22751664 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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