Structural highlights
4pwy is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | GOL, MLI, SAH, UNX |
| Gene: | CAMKMT, C2orf34, CLNMT (HUMAN) |
| Activity: | Calmodulin-lysine N-methyltransferase, with EC number 2.1.1.60 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
[CMKMT_HUMAN] Atypical hypotonia - cystinuria syndrome;2p21 microdeletion syndrome without cystinuria;2p21 microdeletion syndrome.
Function
[CMKMT_HUMAN] Catalyzes the trimethylation of 'Lys-116' in calmodulin.[1]
References
- ↑ Magnani R, Dirk LM, Trievel RC, Houtz RL. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun. 2010 Jul 27;1:43. doi: 10.1038/ncomms1044. PMID:20975703 doi:https://dx.doi.org/10.1038/ncomms1044
