2yq2 | pdb_00002yq2

Structure of BVDV1 envelope glycoprotein E2, pH8

spinqualitylabelsall models 2yq2, resolution 2.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2yq2 is a 2 chain structure with sequence from Bvdv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Related: 2yq3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell attachment, it has been unclear which protein is responsible for membrane fusion. We report the crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 (BVDV1) at both neutral and low pH. Unexpectedly, BVDV1 E2 does not have a class II fusion protein fold, and at low pH the N-terminal domain is disordered, similarly to the intermediate postfusion state of E2 from sindbis virus, an alphavirus. Our results suggest that the pestivirus and possibly the hepacivirus fusion machinery are unlike any previously observed. Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry.,El Omari K, Iourin O, Harlos K, Grimes JM, Stuart DI Cell Rep. 2012 Dec 26. pii: S2211-1247(12)00424-X. doi:, 10.1016/j.celrep.2012.12.001. PMID:23273918 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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