4fuo | pdb_00004fuo

Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms

spinqualitylabelsall models 4fuo, resolution 1.97Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4fuo is a 1 chain structure with sequence from Staeq. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SCN, ZN Related: 4fum, 4fun, 4fup Gene: aap, SERP2398 (STAEQ) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed SignificanceUnder adverse environmental conditions, bacteria can form specialized antibiotic-resistant colonies called "biofilms." In Staphylococcus epidermidis biofilms, a protein, Aap, links bacterial cells together but does so only in the presence of zinc ions. We have determined the atomic structure of an adhesive portion of Aap bound to zinc. The protein adopts an elongated, flexible fold with zinc ions bridging two protein chains. The mode of assembly indicates that Aap is likely to form twisted rope-like structures between bacterial cells. These data provide clues about regions of the protein that could be targeted to prevent intercellular adhesion in the developing biofilm. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms.,Conrady DG, Wilson JJ, Herr AB Proc Natl Acad Sci U S A. 2012 Dec 31. PMID:23277549 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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