4obv | pdb_00004obv
Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)
Structural highlights
Publication Abstract from PubMedSeveral recent studies describe the influence of the gut microbiota on host brain and behavior. However, the mechanisms responsible for microbiota-nervous system interactions are largely unknown. Using a combination of genetics, biochemistry, and crystallography, we identify and characterize two phylogenetically distinct enzymes found in the human microbiome that decarboxylate tryptophan to form the beta-arylamine neurotransmitter tryptamine. Although this enzymatic activity is exceedingly rare among bacteria more broadly, analysis of the Human Microbiome Project data demonstrate that at least 10% of the human population harbors at least one bacterium encoding a tryptophan decarboxylase in their gut community. Our results uncover a previously unrecognized enzymatic activity that can give rise to host-modulatory compounds and suggests a potential direct mechanism by which gut microbiota can influence host physiology, including behavior. Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.,Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001., Epub 2014 Sep 25. PMID:25263219[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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