4dki | pdb_00004dki

Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

spinqualitylabelsall models 4dki, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4dki is a 2 chain structure with sequence from Staac. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BCT, CD, CL, RB6 Gene: mecA, SACOL0033 (STAAC) Activity: Serine-type D-Ala-D-Ala carboxypeptidase, with EC number 3.4.16.4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Methicillin-resistant Staphylococcus aureus (MRSA) is an antibiotic resistant strain of Staphylococcus aureus afflicting hospitals and communities worldwide. Of greatest concern is its development of resistance to current last-line-of-defense antibiotics; new therapeutics are urgently needed to combat this pathogen. Ceftobiprole is a recently developed, latest-generation cephalosporin, and has been the first to show activity against MRSA by inhibiting essential peptidoglycan transpeptidases, including the beta-lactam resistance determinant PBP2a, from MRSA. Here we present the structure of the complex of ceftobiprole bound to PBP2a. This structure provides the first look at the molecular details of an effective beta-lactam:resistant PBP interaction, leading to new insights into the mechanism of ceftobiprole efficacy against MRSA. Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole.,Lovering AL, Gretes MC, Safadi SS, Danel F, De Castro L, Page MG, Strynadka NC J Biol Chem. 2012 Jul 19. PMID:22815485 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Penicillin-binding protein

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