2w9w | pdb_00002w9w

SOLUTION STRUCTURE OF JERDOSTATIN MUTANT R24K FROM TRIMERESURUS JERDONII WITH END C-TERMINAL RESIDUES N45G46 DELETED

spinqualitylabelsall models 2w9w, 40 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2w9w is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2w9v, 2w9u, 2w9o Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed NMR analysis of four recombinant jerdostatin molecules was assessed to define the structural basis of two naturally occurring gain-of-function events: C-terminal dipeptide processing and mutation of the active residue K21 to arginine. Removal of the highly mobile and a bulky C-terminal dipeptide produced pronounced chemical shift changes in the sequentially unconnected but spatially nearby alpha(1)beta(1) inhibitory loop. Analysis of chemical shift divergence and (15)N backbone relaxation dynamics indicated differences in motions in the picosecond to nanosecond time scale, and the higher T(2) rate of S25, S26, and H27 of rJerK21 point to a slowdown in the microsecond to millisecond motions of these residues when compared with rJerR21. The evidence presented in this article converges on the hypothesis that dynamic differences between the alpha(1)beta(1) recognition loops of rJerR21 and rJerK21 may influence the thermodynamics of their receptor recognition and binding. A decrease in the mus-ms time scale may impair the binding affinity by reducing the rate of possible conformations that the rJerK21 can adopt in this time scale. NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin alpha1beta1.,Carbajo RJ, Sanz L, Mosulen S, Perez A, Marcinkiewicz C, Pineda-Lucena A, Calvete JJ Proteins. 2011 Aug;79(8):2530-42. doi: 10.1002/prot.23076. Epub 2011 Jun, 7. PMID:21656569 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Disintegrin

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