TNF receptor-associated factor

spinqualitylabelsall models Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF1 is the only TRAF which does not have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK. TRAF3 mediates some innate immune receptor signals and regulates some post-translational modifications. TRAF4 is a binding partner of glycoproteins in platelets. Structural highlights The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions.

3D Structures of TNF receptor-associated factor

Updated on 15-September-2016

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• TRAF1
  • 3m0d – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human
    
• TRAF2
  • 1ca4 – hTRAF2 TRAF domain residues 334-501
    
  • 3knv – hTRAF2 RING+zinc finger 1 domains residues 1-133
    
  • 3m06 – hTRAF2 residues 266-329
    
• TRAF2 complex with peptide
  • 1ca9 – hTRAF2 TRAF domain + TNF-R2 peptide
    
  • 1qsc, 1d00, 1czz – hTRAF2 TRAF domain + CD40 receptor peptide
    
  • 1d01 – hTRAF2 TRAF domain + CD30 peptide
    
  • 1czy – hTRAF2 TRAF domain + latent membrane protein peptide
    
  • 1d0a – hTRAF2 TRAF domain + OX40L receptor peptide
    
  • 1d0j – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide
    
  • 1f3v – hTRAF2 TRAF domain + TRADD N terminal
    
  • 3m0a – hTRAF2 residues 266-329 + cIAP2
    
• TRAF3
  • 4ghu – TRAF3 TRAF domain residues 376-567 + antiviral-signaling protein peptide - mouse
    
• TRAF4
  • 4k8u, 3zjb, 4m4e – hTRAF4 TRAF domain residues 281-470
    
• TRAF5
  • 4gjh – hTRAF5 TRAF domain residues 381-558
    
• TRAF6
  • 1lb4 – hTRAF6 TRAF domain
    
  • 2jmd, 2eci – hTRAF6 RING domain - NMR
    
  • 3hcs – hTRAF6 RING+zinc finger 1-3 domains
    
• TRAF6 complex with peptide
  • 1lb5 – hTRAF6 TRAF domain + RANK peptide
    
  • 1lb6 – hTRAF6 TRAF domain + CD40 antigen peptide
    
  • 3hct, 3hcu – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2
    
  • 4z8m – hTRAF6 TRAF domain + antiviral-signaling protein peptide
    

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