5kvp | pdb_00005kvp

Solution structure of the catalytic domain of zoocin A

spinqualitylabelsall models 5kvp, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5kvp is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: UNL, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Zoocin A is a Zn-metallopeptidase secreted by Streptococcus zooepidemicus strain 4881. Its catalytic domain is responsible for cleaving the D-alanyl-L-alanine peptide bond in streptococcal peptidoglycan. The solution NMR structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain (rCAT C74A) has been determined. With a previous structure determination for the recombinant target recognition domain (rTRD), this completes the 3D structure of zoocin A. While the structure of rCAT C74A resembles those of the catalytic domains of lysostaphin and LytM, the substrate binding groove is wider and no tyrosine residue was observed in the active site. Proteins 2016. (c) 2016 Wiley Periodicals, Inc. Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A.,Xing M, Simmonds RS, Timkovich R Proteins. 2016 Oct 3. doi: 10.1002/prot.25178. PMID:27699884 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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