5fah | pdb_00005fah

KALLIKREIN-7 IN COMPLEX WITH COMPOUND1

spinqualitylabelsall models 5fah, resolution 1.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fah is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5VT, ACT Activity: Stratum corneum chymotryptic enzyme, with EC number 3.4.21.117 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [KLK7_HUMAN] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

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