5fck | pdb_00005fck

COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 5

spinqualitylabelsall models 5fck, resolution 1.86Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fck is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5WC, SO4 Activity: Complement factor D, with EC number 3.4.21.46 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Function [CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

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