Aerolysin

spinqualitylabelsall models Proaerolysin dimer (PDB code 1pre). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Aerolysin (Aer) is a channel-forming toxin from Aeromonas hydrophyla. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. For toxins in Proteopedia see Toxins.

3D Structures of Aerolysin

Updated on 01-November-2016

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• Aerolysin

• • Toxins, 3g4o – Aer (mutant)
    
  • 5jzh, 5jzt, 5jzw - Aer pore - CryoEM
    
• Proaerolysin
  • 1pre - proAer
    
  • 3c0m, 3c0n, 1z52 - proAer (mutant)
    
  • 3c0o - proAer (mutant)+mannose-6-phosphate

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel