Thermolysin

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thermolysin (TML) is a thermostable metalloproteinase enzyme from Bacillus thermoproteolyticus. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. See Metalloproteases and Matrix metalloproteinase for discussion. Structural highlights Thermolysin is a well researched metalloprotease containing zinc (click this!) and the amino acids His-Glu-X-His-His as its catalytic center. Glu-166, His-142 and -146 are grouped around the zinc atom, holding it fast, while Glu-143 holds the polarized water atom. Additionally, Tyr-157 and His-231 stabilize the substrate protein which will be cleaved into two smaller proteins..

3D Structures of Thermolysin

Updated on 27-November-2016

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• Thermolysin
  • Metalloproteases, Matrix metalloproteinase, metalloprotease, 3do0, 3do1, 3do2, 2g4z, 2a7g, 1gxw, 1kei, 1l3f, 1tlx, 2tlx, 8tln, 3p7p, 3p7q, 3p7r, 3p7s, 3p7t, 3p7u, 3p7v, 3p7w, 3zi6 – TML
    
  • 3ls7, 4ow3, 4tnl - TML residues 233-548
    
  • 1trl - TML residues 255-316 – NMR
    
  • 3fxs, 3fbo, 3eim, 1lna, 1lnb, 1lnc, 1lnd, 1lne, 1lnf - TML residues 233-548+metal ion replacing Ca
    
• Thermolysin TML+transition state analog
  • 1tlp, 1tmn, 2tmn, 4tmn, 5tmn – TML+transition state analog
    
• Thermolysin + amino acid
  • 1kl6 – TML+ alanine
    
  • 4m65 – TML + asparagine
    
  • 3qgo – TML + phenylalanine methyl ester
    
  • 3qh1 – TML + benzyloxycarboxyl- aspartate
    
  • 3qh5 – TML + benzyloxycarboxyl- aspartate + phenylalanine methyl ester
• Thermolysin + dipeptide
  • 2wi0, 3tmn – TML+ dipeptide
    
  • 3fgd - TML residues 233-548+dipeptide
    
• Thermolysin + inhibitor
  • 1fjo, 1fj3, 1fjq, 1fjt, 1fju, 1fjv, 1fjw, 4tli, 5tli, 6tli, 7tli, 8tli, 1tli, 2tli, 3tli – TML soaked in organic solvents
    
  • 3fv4, 3fxp, 3flf, 3fb0, 3fcq, 3f28, 3f2p, 4mtw, 4mwp, 4mxj, 4mzn, 4n4e, 4n5p, 4n66, 4oi5 – TML residues 233-548+inhibitor
    
  • 3for, 1y3g, 1zdp, 1z9g, 1pes, 1pe7, 1pe8, 1os0, 1kto, 1ks7, 1kro, 1kr6, 1kkk, 1kjo, 1kjp, 1qf0, 1qf1, 1qf2, 1hyt, 1thl, 6tmn, 7tln, 4tln, 5tln, 1pe5, 3ms3, 3msa, 3msf, 3msn, 3n21, 3nn7, 3t73, 3t74, 3t87, 3t8c, 3t8d, 3t8f, 3t8g, 3t8h, 4h57, 4d9w, 4d91 – TML+inhibitor
    
  • 3ssb – TML + Impi-α
    
  • 3t2h – TML + trimethylamine oxide
    
  • 3t2i – TML + sarcosine
    
  • 3t2j – TML + betaine
    

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Alexander Berchansky, Michal Harel