5ego | pdb_00005ego

HOXB13-MEIS1 heterodimer bound to methylated DNA

spinqualitylabelsall models 5ego, resolution 2.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ego is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: 5CM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [MEIS1_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. Function [HXB13_HUMAN] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. [MEIS1_HUMAN] Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

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