5fak | pdb_00005fak

Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Adenine

spinqualitylabelsall models 5fak, resolution 1.87Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fak is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADE, SO4 Related: 4l6i, 4l5a, 4l5c, 4l5y, 5f73, 5f76, 5f77, 5f78, 5f7j, 5f7o, 5f7x, 5f7z Activity: S-methyl-5'-thioadenosine phosphorylase, with EC number 2.4.2.28 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [I0B503_SCHMA] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155]

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