| describing Jmol [1] to the rescue.
Function
Polyhydroxybutyrate synthase (PHBS) or PHB synthase catalyze the polymerization of β-hydroxybutyryl coenzyme A to generate polyhydroxybutyrate[2].
For details see PHB synthase in Rhodobacter sphaeroides.
Relevance
PHB is of interest as bio-derived and biodegradable plastics.
Structural highlights
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423
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3D structures of PHB synthase
PHB synthase in Rhodobacter sphaeroides, 5hz2 - PHBS catalytic domain - Cupriavidus necator
References
