OBrochtasSandbox
From Proteopedia
==O'Brochta's Sandbox == 0 <StructureSection load='Model.itasser.relax.pdb' size='400' side='right' caption='Anopheles arabiensis InR kinase domain model' scene=>
The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'
This shows the basic structure of the kinase domain with an N and C lobe. The ATP will sit between them just below Beta 1
This shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a spacefilled model.
These are three ts mutations found in other RTKs
G1000S (magenta) A1133G (orange) T1221I (teal)
