OBrochtasSandbox

==O'Brochta's Sandbox == 0 <StructureSection load='Model.itasser.relax.pdb' size='400' side='right' caption='Anopheles arabiensis InR kinase domain model' scene='Kinase_n_and_c_lobes'>

The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'

This shows the basic structure of the kinase domain with an N and C lobe. The ATP will sit between them just below Beta 1

This shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a spacefilled model.

These are three ts mutations found in other RTKs.

G1000S (magenta), A1133G (orange), T1221I (teal)

And as a spacefilled model

Proteopedia Page Contributors and Editors (what is this?)

David O'Brochta