5kdv | pdb_00005kdv

IMPa metallopeptidase from Pseudomonas aeruginosa

spinqualitylabelsall models 5kdv, resolution 1.93Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5kdv is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, SO4, ZN Related: 5kd2, 5kd5, 5kd8, 5kdj, 5kdn, 5kds, 5kdu, 5kdw, 5kdx Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [IMPA_PSEAE] Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31.

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