4uvq | pdb_00004uvq

PatG Domain of Unknown Function

spinqualitylabelsall models 4uvq, resolution 1.72Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4uvq is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN NonStd Res: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological `toolkit' to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated. The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.,Mann G, Koehnke J, Bent AF, Graham R, Houssen W, Jaspars M, Schwarz-Linek U, Naismith JH Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1597-603. doi:, 10.1107/S2053230X1402425X. Epub 2014 Nov 14. PMID:25484206 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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