Rac

spinqualitylabelsall models Human Rac1 (grey) complex with YpkA (pink) and GDP (PDB code 2h7v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Ras1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes. Ras3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. Disease Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome. Structural highlights The interactions between Rac1 and YpkA are via switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA.

3D structures of Rac

Updated on 12-February-2017

{"openlevels":0}

• Rac1
  • 3th5, 1ryh, 1mh1 – hRac1 + GNP – human
    
  • 2p2l, 1ryf – hRac1 + GDP
    
  • 4gzl, 3sbd, 3sbe – hRac1 (mutant) + GNP
    
  • 4gzm – hRac1 (mutant) + GSP
    
  • 5hzh, 2wkp, 2wkq, 2wkr – hRac1 LOV2 domain (mutant) + GTP + MFN
    
• Rac1 complex with protein
  • 5fi0 – hRac1 + PTDINS (3,4,5)-dependent Rac exchanger
    
  • 4yon – hRac1 (mutant) + PTDINS (3,4,5)-dependent Rac exchanger
    
  • 2yin – hRac1 + dedicator of cytokinesis protein 2
    
  • 3b13 – hRac1 (mutant) + dedicator of cytokinesis protein 2
    
  • 3bji, 2vrw – hRac1 + proto-oncogene VAV
    
  • 2nz8 – hRac1 + triple functional domain protein
    
  • 1foe – hRac1 + TIAM1
    
• Rac1 complex with protein and nucleotide
  • 3ryt – hRac1 (mutant) + plexin-A1 + GNP
    
  • 3su8, 3sua – hRac1 (mutant) + plexin-B1 + GNP
    
  • 2rmk – hRac1 (mutant) + PRK1 + GCP - NMR
    
  • 2fju – hRac1 + phospholipase C beta 2 + GSP
    
  • 2h7v – hRac1 (mutant) + YpkA + GDP
    
  • 1hh4, 1ds6 – hRac1 + RhoGD1 + GDP
    
  • 1i4d, 1i4l – hRac1 + arfaptin + GDP
    
  • 1i4t – hRac1 + arfaptin + GNP
    
  • 1g4u – hRac1 (mutant) + SPTP + GDP
    
  • 1he1 – hRac1 + GTPase-activating protein + GDP
    
  • 1e96 – hRac1 (mutant) + neutrophil cytosol factor 2 + GTP
    
• Rac2
  • 2w2t – hRac2 (mutant) + GDP
    
  • 2w2v – hRac2 (mutant) + GDTP
    
  • 2w2x – hRac2 (mutant) + PLCG2 + GSP
    
• Rac3
  • 2qme – hRac3 + PAK1 + GCP
    
  • 2ov2 – hRac3 + PAK4 + GCP
    
  • 2ic5 – hRac3 + GDP + GNP
    
  • 2g0n, 2c2h – hRac3 + GDP
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman