1t7s | pdb_00001t7s
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| 1t7s, resolution 2.80Å | |||||||||||||
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| Ligands: | MSE | ||||||||||||
| Gene: | Bag-1 (Caenorhabditis elegans) | ||||||||||||
| Domains: | BAG, PRK07577 | ||||||||||||
| Related: | 1HX1, 1I6Z
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein
Overview
Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
About this Structure
1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932
Page seeded by OCA on Sun Mar 30 23:52:34 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Caenorhabditis elegans
- Single protein
- Bunzel, R.
- Li, S.
- Luan, C H.
- Luo, M.
- Pruett, P.
- SECSG, Southeast Collaboratory for Structural Genomics.
- Schormann, N.
- Symersky, J.
- Zhang, Y.
- Bag-1 cochaperone
- Protein structure initiative
- Psi
- Secsg
- Southeast collaboratory for structural genomic
- Structural genomic
