5lua

Crystal structure of human legumain (AEP) in complex with compound 11b

spinqualitylabelsall models 5lua, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5lua is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5KN, NAG NonStd Res: SNN Activity: Legumain, with EC number 3.4.22.34 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

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