Gcn4

spinqualitylabelsall models Structure of Gcn4 leucine zipper domain complex with DNA (PDB entry 2dgc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gcn4 is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also Intrinsically Disordered Protein. Structural highlights Gcn4 and other family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical.

3D Structures of Gcn4

Updated on 24-May-2017

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• Gcn4 coiled-coil domain
  • Intrinsically Disordered Protein, 1w5i, 2b1f, 2b22, 2ag3, 2r2v, 4c46, 4hu5, 4hu6 – yGcn4 - yeast
    
  • 2ovn, 2l56, 5iir, 5iiv, 5iew – yGcn4 - NMR
    
  • 3ck4, 3crp, 2ipz – yGcn4 tetramer
    
  • 1gcl, 1swi, 1ce9, 1w5g, 1w5h, 1w5j, 1w5k, 1w5l, 1unt, 1unu, 1unv, 1unw, 1unx, 1uny, 1unz, 1uo0, 1uo1, 1uo2, 1uo3, 1uo4, 1uo5, 1u9f, 1u9g, 1u9h, 2bni, 2cce, 2ccf, 2ccn, 2ahp, 2hy6, 3i1g, 2wpy, 2wpz, 2wq0, 2wq1, 2wq2, 2wq3, 3k7z, 3gjp, 3m48, 4niz, 4nj0, 4nj1, 4nj2, 4tl1, 5apq, 5aps, 5apt, 5apu, 5apv, 5apw, 5apx, 5apy – yGcn4 (mutant)
    
  • 1zii, 1zik, 1zil – yGcn4 dimer (mutant)
    
  • 2o7h, 1gcm, 1zij, 1zim, 1piq, 1ij0, 1ij1, 1ij2, 1ij3, 1rb4, 1rb5, 1rb6 – yGcn4 trimer (mutant)
    
  • 2nrn – yGcn4 tetramer (mutant)
    
  • 1fmh – yGcn4 dimer (mutant) - NMR
    
  • 1ysa, 1dgc, 2dgc – yGcn4 dimer + DNA
    
• Gcn4-pLI
  • 2ag3, 2oxj, 2oxk – yGcn4-pLI (br />
  • 1u2u – yGcn4-pLI dimer - NMR
    
  • 4dmd, 1kd8, 1kd9, 1kdd – yGcn4-pLI dimer
    
  • 4dme – yGcn4-pLI trimer
    
  • 1c94 – yGcn4-pLI retro
    
• Gcn4 transcription activation domain
  • 2lpb – yGcn4 + mediator of RNA polymerase II
    
• Gcn4 fusion proteins
  • 1gk6 – yGcn4/vimentin
    
  • 2wg5 – yGcn4/proteasome-activating nucleotidase
    
  • 2wg6 – yGcn4 (mutant)/proteasome-activating nucleotidase
    
  • 2yny, 2ynz, 2yo0, 2yo1, 2yo2, 2yo3, 3zmf – yGcn4/inner membrane protein
    
  • 5app – yGcn4/outer membrane protein 100
    
  • 5apz – yGcn4/NOR1
    
  • 3i5c – yGcn4/WSPR response regulator
    
  • 3p8m – yGcn4/dynein
    
  • 4g2k, 1env, 1fav, 1gcl, 2q5u, 2q7c, 3g9r – yGcn4/virus envelope glycoprotein
    
  • 1kql, 2z5i – yGcn4/α-tropomyosin
    
  • 2z5h – yGcn4/α-tropomyosin + troponin T
    
  • 3bas, 3bat – yGcn4/myosin
    
  • 1wvl, 2d3e, 2efr, 2efs, 2g9j – yGcn4/SAC7D + DNA
    
  • 4m8m – yGcn4/plexin
    
• Gcn4 complex with protein
  • 1ld4 – yGcn4 + virus coat protein + virus spike glycoprotein
    

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Michal Harel, Karsten Theis, Alexander Berchansky