5v56 | pdb_00005v56

2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114

spinqualitylabelsall models 5v56, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5v56 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 836, FMN, NAG Related: 5v57 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

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