Transducin

spinqualitylabelsall models Structure of rat transducinα (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code 1gp2). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Transducin (TDN) or Heterotrimeric G protein or Guanine nucleotide-binding protein G is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. Disease Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit.

3D structures of transducin

Updated on 02-July-2017

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• Transducin-α
  • 1tnd – bTDN + GTPγS - bovine
    
  • 1tag – bTDN + GDP
    
  • 3v00 – b/ratTDN + GDP
    
  • 1tad – bTDN + GDP + AlF4
    
  • 1fqk – bTDN + RGS9 + GDP + AlF4
    
  • 1fqj – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4
    
• Transducin-βγ
  • 1tbg – bTDN
    
  • 2trc, 1a0r, 1b9x, 1b9y – bTDN + phosducin
    
  • 1omw, 3cik – bTDN + G-protein coupled receptor kinase 2
    
  • 3v5w – bTDN (mutant) + G-protein coupled receptor kinase 2
    
  • 3psc, 3pvu, 3pvw, 4mk0 – bTDN + β-adrenergic receptor kinase 1
    
  • 5he0, 5he1, 5he2, 5he3 – hTDN + β-adrenergic receptor kinase 1 + inhibitor
    
  • 4pnk – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor
    
  • 2bcj – bTDN (mutant) + β-adrenergic receptor kinase 1
    
  • 3uzs – bTDN + β-adrenergic receptor kinase 1 + RNA
    
  • 3krw, 3krx – bTDN + G-protein coupled receptor kinase 2 + inhibitor
    
  • 1xhm – bTDN + peptide
    
  • 4kfm – hTDN + G-protein activated inward rectifier K+ channel
    
• Transducin-α+βγ
  • 1got – bTDN + GDP
    
  • 1gg2 – TDN rα (mutant) + bβγ + GDP - rat
    
  • 1gp2, 5kdo – TDN rα + bβγ + GDP
    
  • 3ah8 – TDN rα + bβ + bγ (mutant) + GDP + inhibitor
    
  • 3sn6 – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment
    
  • 5tdh – TDN hα (mutant) + rβ + bγ + GDP
    

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman