MECDP synthase

spinqualitylabelsall models Se-Met MECDP synthase trimer complex with CDP, sulfate, Mn+2 (purple) and Zn+2 (grey) ion, 1gx1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function MECDP synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. Relevance MECPS is a potential antimalarial drug target. Structural highlights MECPS active site is located in a cleft between 2 subunits and contains the metal ions. Water molecules shown as red spheres.

3D structures of MECDP synthase

Updated on 19-July-2017

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• MECPS
  • 1knk - EcMECPS + Mn – Escherichia coli
    
  • 1u3p - EcMECPS + Zn
    
  • 3f0d - BpMECPS + Zn – Burkholderia pseudomallei
    
  • 3f0e - BpMECPS + Mg + Zn
    
  • 1jn1 - HiMECPS + Co – Haemophilus influenzae
    
  • 1vh8 - HiMECPS
    
  • 1vha - HiMECPS + Mn
    
  • 1iv1 - TtMECPS – Thermus thermophilus
    
  • 3f6m - YpMECPS – Yersinia pestis
    
  • 1iv3 - TtMECPS (mutant) + Mg
    
  • 3ghz - MECPS + Mg – Salmonella typhimurium
    
  • 3re3 - MECPS – Francisella tularensis
    
  • 4c82 - PfMECPS (mutant) + Zn – Plasmodium falciparum
    
  • 5iwx - BsMECPS + Mg – Bacillus subtilis
    
• MECPS binary complex
  • 1gx1 - EcMECPS + CDP + Mn + Zn
    
  • 1u3l - EcMECPS + CDP + Mg + Zn
    
  • 3f0f - BpMECPS + CMP + Mg + Zn
    
  • 3ike - BpMECPS + cytosine + Mg + Zn
    
  • 3k2x, 3ke1 - BpMECPS + cytosine derivative + Zn
    
  • 3ikf, 3k14, 3q8h - BpMECPS + imidazo-thiazol derivative + Zn
    
  • 3f0g, 3ieq - BpMECPS + CMP + Zn
    
  • 2uzh - MECPS + CDP + Zn – Mycobacterium smegmatis
    
  • 4c81 - PfMECPS (mutant) + CDP + Zn
    
  • 3fpi - YpMECPS + CTP + Mg
    
  • 5b8f - MECPS + CMP + Mg – Pseudomonas aeruginosa
    
  • 5iwy - BsMECPS + CMP + Mg
    
  • 1iv2 - TtMECPS (mutant) + CDP + Mg
    
  • 1iv4 - TtMECPS (mutant) + CMP + Mg
    
  • 1h47 - EcMECPS + CMP + Zn
    
  • 3jvh - BpMECPS + pyrimidine derivative + Zn
    
  • 1u40 - EcMECPS + CDME + Zn
    
  • 1u43 - EcMECPS + 2P-CDME
    
  • 1t0a - MECPS + farnesyl phosphate + Co + Zn - Shewanella oneidensis
    
  • 2pmp - MECPS + CMP + Zn – Arabidopsis thaliana
    
  • 4c8e, 4c8g - BcMECPS + CMP + Zn – Burkholderia cenocepacia
    
  • 4c8i - BcMECPS + citrate + Zn
    
• MECPS ternary complex
  • 3iew - BpMECPS + CDP + CTP + Zn
    
  • 1jy8 – EcMECPS + MECP + CMP + Zn
    
  • 1knj - EcMECPS + MECP + CMP + Mn
    
  • 3mbm - BpMECPS + imidazo-thiazol derivative +cytosine + Zn
    
  • 3p10 - BpMECPS + pyrimidine derivative + cytidine + Zn
    
  • 3t80 - MECPS + pyrimidine derivative + cytidine + Zn – Salmonella enterica
    
  • 1yqn – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn
    
  • 2amt - EcMECPS + CMP derivative + geranyl diphosphate + Zn
    
  • 3elc, 3eor, 3ern, 3fba - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn
    
  • 3esj - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn
    
  • 2gzl - EcMECPS + inhibitor + geranyl diphosphate + Zn
    
• MECPS quaternary complex
  • 3p0z, 3qhd - BpMECPS + imidazo derivative + pyrimidine derivative + cytidine + Zn
    
  • 1h48 - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn
    

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Michal Harel, Alexander Berchansky