3zpg | pdb_00003zpg

Acinetobacter baumannii RibD, form 2

spinqualitylabelsall models 3zpg, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zpg is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 5GP, ACT, CAC, CL, OXL, SO4, ZN Related: 3zpc Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [D0CB74_ACIBA] Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.[PIRNR:PIRNR006769] Publication Abstract from PubMed The bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (RibD) represents a potential antibacterial drug target. The structure of recombinant Acinetobacter baumannii RibD is reported in orthorhombic and tetragonal crystal forms at 2.2 and 2.0 A resolution, respectively. Comparisons with orthologous structures in the Protein Data Bank indicated close similarities. The tetragonal crystal form was obtained in the presence of guanosine monophosphate, which surprisingly was observed to occupy the adenine-binding site of the reductase domain. Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.,Dawson A, Trumper P, Chrysostomou G, Hunter WN Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi:, 10.1107/S174430911301292X. Epub 2013 May 23. PMID:23722836 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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