Neuropilin

spinqualitylabelsall models Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) 2qqm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A. NRP-2 has high affinity for semaphorin-3F. Relevance NRP are highly expressed in human neoplasms. Structural highlights NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region. Ca coordination site. Water molecule shown as red sphere.

3D Structures of Neuropilin

Updated on 21-August-2017

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• NRP-1
  • 1kex – hNRP-1 B1 domain – human
  • 2qqm - hNRP-1 A2+B1+B2 domains
    
  • 4deq - hNRP-1 B1 domain + VEGF-A heparin-binding domain
    
  • 2qqn - hNRP-1 B1 domain + VEGF-blocking antibody
  • 3i97 - hNRP-1 B1 domains + inhibitor
  • 2orx – rNRP-1 B domains – rat
  • 2orz – rNRP-1 B domains + tuftsin peptide
    
  • 4gz9 - mNRP-1 A1+A2+B1+B2 domain – mouse
    
  • 4gza - mNRP-1 A1+A2+B1+B2 domains + plexin A2 + semaphorin 3A
• NRP-2
  • 4qdq, 4qds - hNRP-2 B1+B2 domains
    
  • 2qqj - hNRP-2 B1+B2 domains
    
  • 4qdr - hNRP-2 B1+B2 domain (mutant)
    
  • 2qqo - hNRP-2 A2+B1+B2 domains

• • 2qqk, 2qql - hNRP-2 A+B domains + semaphorin-blocking antibody

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Michal Harel, Alexander Berchansky, Joel L. Sussman