Protein phosphatase

spinqualitylabelsall models Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate 3k7v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Protein phosphatases (PP) regulate protein phosphorylation and thus are key in intracellular signal transduction processes. PP1 is a serine/threonine phosphatase and is a key component of the insulin signaling pathway. PP2A targets proteins in the oncogenic signaling pathways. For PP2A see also HEAT Repeat. PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see ABA-regulated Protein Phosphatase 2C. PP4 regulates a variety of cellular functions. PP5 is activated by lipids and is involved in signal transduction. Disease Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols. Development of Alzheimer disease drugs could be based on restoration of PP2A activity. Structural highlights Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin. Algal toxin binds at the surface pocket of the PP2A catalytic subunit which contains the Mn+2 ion cofactors. Water molecule shown as red sphere. Mn+2 ion cofactors coordination site. Whole binding site.

3D Structures of protein phosphatase

Updated on 21-September-2017

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• Protein phosphatase 1A
  • HEAT Repeat, ABA-regulated Protein Phosphatase 2C, 3fxl, 3fxm, 3fxo, 4ra2 – hPP1A + Mn – human
    
  • 4da1 – hPP1K + Mn
    
  • 3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
    
  • 3v4y – hPP1A catalytic subunit + PP1 nuclear inhibitor
    
  • 4g9j, 5ioh – hPP1A catalytic subunit + peptide
    
  • 5inb, 5j28 - hPP1G catalytic subunit + peptide
    
  • 2rlt – PP1 regulatory subunit – pig - NMR
    
• Protein phosphatase 2A
  • 1b3u, 2g62, 2hv6 – hPP2A regulatory subunit
    
  • 2ie3, 2ie4, 2npp, 2nyl, 2nym – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
    
  • 3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
    
• Protein phosphatase 2C
  • 2iq1 – hPP2C κ
    
  • 3d8k – PP2C – Toxoplasma gondii
    
  • 3jrq, 3nmn – AtPP2C + Pyl1 – Arabidopsis thaliana
    
  • 3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
    
  • 4la7, 4lg5, 4lga, 4lgb – AtPP2C + Pyl2 + ligand
    
  • 4ds8 – AtPP2C + Pyl3 + Mn
    
  • 3rt0 – AtPP2C (mutant) + Pyl10
    
  • 4n0g – AtPP2C + Pyl13
    
  • 3qn1, 3zvu, 4wvo – AtPP2C + Pyr1
    
  • 3ujk – AtPP2C
    
  • 4yzg – AtPP2C (mutant)
    
  • 4yzh – AtPP2C (mutant) + chlorophyll-binding protein peptide
    

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Michal Harel, Alexander Berchansky, Alexsandra Tifane Santos do Nascimento, Joel L. Sussman