Retinol-binding protein

spinqualitylabelsall models Human cellular retinol-binding protein II complex with retinol, sulfate and tartarate, 2rct Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Retinol-binding protein (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. Plasma RBP (PRBP) carries retinol in blood while cellular RBP (CRBP) carries retinol in the cell. Relevance RBP is used to assess vitamin A deficiency as it binds 1:1 to retinol. RBP IV is used as biomarker for renal dysfunction and cardiovascular disease in type II diabetes. Structural highlights Retinol binds to cellular RBP II inside its internal cavity. Active site. Water molecules shown as red spheres.

3D structures of retinol-binding protein

Updated on 26-September-2017

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• Plasma retinol-binding protein (PRBP)
  • 1rbp, 1jyd, 1brp, 1brq - hRBP – human
    
  • 1jyj - hRBP (mutant)
    
  • 1aqb - RBP – pig
    
  • 1hbq – bRBP – bovine
    
• Plasma RBP complex
  • 3bsz - hRBP II + transthyretin + antibody + retinol
    
  • 3fmz - hRBP IV + non-retinoid ligand
    
  • 2wq9 - hRBP IV + oleate
    
  • 2wr6 - hRBP IV + linoleate
    
  • 2wqa - hRBP IV + transthyretin + oleate
    
  • 4o9s, 4psq - hRBP IV + non-retinoid
    
  • 1iiu - RBP + retinol – chicken
    
  • 1rlb - cRBP + transthyretin
    
  • 1kt3, 1kt4, 1kt5, 1kt6, 1kt7, 1hbp - RBP + retinol
    
  • 1erb, 1fel, 1fem, 1fen - bRBP + retinol derivative
    
  • 1qab - rRBP + transthyretin
    
• Cellular RBP (CRBP)
  • 1jbh, 1kgl, 1mx7 - rRBP I – rat - NMR
    
  • 5h9a, 5ljb, 5ljc, 5ljg, 5ljk - hRBP I
    
  • 5ljd, 5lje, 5ljh - hRBP I (mutant)
    
  • 1b4m - rRBP II – NMR
    
  • 1opa – rRBP II
    
  • 2rcq, 4zh9 - hRBP II
    
  • 4zgu, 4zh6, 4zr2, 4zcb, 5dg4, 5dpq - hRBP II (mutant)
    
  • 1ggl - hRBP III
    
  • 1lpj, 6at8 - hRBP IV
    
  • 1kqx – ZeRBP – zebrafish
    
  • 4uet - NaRBP – Necator americanus - NMR
    
• Cellular RBP complex
  • 1mx8 - rRBP I + retinol – NMR
    
  • 5h8t, 5hbs - hRBP I + retinol
    
  • 5ha1 - hRBP I + retinol derivative
    
  • 1eii - rRBP II + retinol – NMR
    
  • 2rct, 4qyn, 4qyp, 4qzt, 4qzu - hRBP II + retinol
    
  • 4zj0, 4ruu, 4ede, 4eej, 4efg, 4exz, 4gkc, 5f6b, 5f7g, 5ffh, 5f58, 5faz, 5fen - hRBP II (mutant) + retinol
    
  • 1kqw - ZeRBP + retinol
    
  • 1crb, 1opb - rRBP + retinol
    
  • 4xcp - NaRBP + palmitate
    
• Nematode and fatty acid RBP
  • 4xcp - hhRBP - human hookworm
    
  • 4uet - hhRBP - NMR
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman