5wiu | pdb_00005wiu

Structure of the human D4 Dopamine receptor in complex with Nemonapride

spinqualitylabelsall models 5wiu, resolution 1.96Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wiu is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: AQD, GOL, OLA, PEG, PO4 Related: 5wiv Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [DRD4_HUMAN] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

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