2ig7 | pdb_00002ig7

Crystal structure of Human Choline Kinase B

spinqualitylabelsall models 2ig7, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ig7 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: UNX NonStd Res: MSE Gene: CHKB, CHETK, CHKL (HUMAN) Activity: Choline kinase, with EC number 2.7.1.32 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CHKB_HUMAN] Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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