Complement C4

spinqualitylabelsall models Glycosylated human complement C4-Aα chain (grey), C4 β (green) and γ chain (pink) (PDB code 4fxk) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Complement C4 (CC4) is part of the complement pathway. CC4 is a mixture of CC4-A and CC4-B. CC4 is part of the complement cascade which results in pathogen cell membrane pore and the eventual lysis of the pathogen cell. Disease C4 deficiency causes lupus-like autoimmunity. Copy number variations of complement C4 are associated with Behcet's disease. Level of complement C4 is associated with persistence and disease progression of chronic hepatitis C.

3D structures of complement C4

Updated on 20-October-2017

5jpn, 5jtw – hCC4-A - human
5jpm – hCC4-A + mannan-binding lectin serine protease
4xam – hCC4-A + hCC4-B
4fxk – hCC4-A α chain + hCC4 β+γ chains
4fxg – hCC4-A α chain + hCC4 β+γ chains + mannan-binding lectin serine protease

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Michal Harel, Joel L. Sussman