5aoh | pdb_00005aoh

Crystal Structure of CarF

spinqualitylabelsall models 5aoh, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5aoh is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: K Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The natural production of the beta-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived. 1.8 A resolution crystal structure of the carbapenem intrinsic resistance protein CarF.,Tichy EM, Hardwick SW, Luisi BF, Salmond GPC Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):549-556. doi:, 10.1107/S2059798317002236. Epub 2017 Jun 22. PMID:28695855 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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