Peregrin

spinqualitylabelsall models Human peregrin bromodomain complex with ligand and nitrate (PDB code 5c85) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Peregrin (BRPF1) is a chromatin regulator and plays a scaffolding role in transcription. It is essential for development of fetal hematopoietic stem cells. Disease Mutations in BRPF1 cause intellectual disability and deficient histone acetylation. Structural highlights BRPF1 consists of 2 PHD fingers, bromodomain and a PWWP domain for recognizing multiple histone modifications. PRPF1 bromodomain binds the ligand.

3D structures of peregrin

Updated on 21-October-2017

{"openlevels":0}

• Peregrin
  • 3l42 – hBRPF1 PWWP domain - human
    
  • 5erc – hBRPF1 PZP domain
    
  • 4lc2 – hBRPF1 bromodomain
    
  • 2d9e – hBRPF1 bromodomain - NMR
    
• Peregrin complexes
  • 5ewv, 5eww, 5c89, 5g4r, 5g4s, 5em3, 5ev9, 5eva, 5ewh, 5c85, 5c87, 5d7x, 5dy7, 5d7a, 5dyc, 5e3d, 5e3g, 5epr, 5eps, 5eq1, 5etb, 5etd, 5ewc, 5ewd, 5ffy, 5c7n, 4uye, 5dya – hBRPF1 bromodomain + ligand
    
  • 5ffv, 5ffw, 4qyd, 4qyl – hBRPF1 bromodomain + histone peptide
    
  • 2rs9 – hBRPF1 bromodomain + histone peptide - NMR
    
  • 3mo8, 2x4w, 2x4x, 2x4y, 2x35 – hBRPF1 PWWP domain + histone peptide
    
  • 5fg5, 5fg4, 5myg – hBRPF1 bromodomain + chemical probe
    
  • 5t4u, 5t4v – hBRPF1 bromodomain + inhibitor
    
  • 5c6s – hBRPF1 PWWP domain + ligand
    

Proteopedia Page Contributors and Editors (what is this?)

Brian Boyle, Michal Harel, Alexander Berchansky, Joel L. Sussman