3hd0 | pdb_00003hd0

Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima

spinqualitylabelsall models 3hd0, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3hd0 is a 3 chain structure with sequence from Atcc 43589. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: MSE Gene: nfi, TM_1865 (ATCC 43589) Activity: Deoxyribonuclease V, with EC number 3.1.21.7 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [NFI_THEMA] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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