1od8 | pdb_00001od8

Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-isofagomine lactam

spinqualitylabelsall models 1od8, resolution 1.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1od8 is a 1 chain structure with sequence from "actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: IMD, NA, XDL, XYP Related: 1e0v, 1e0w, 1e0x, 1knl, 1knm, 1mc9, 1xas Activity: Endo-1,4-beta-xylanase, with EC number 3.2.1.8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [XYNA_STRLI] Contributes to hydrolyze hemicellulose, the major component of plant cell-walls. XLNA and XLNB seem to act sequentially on the substrate to yield xylobiose and xylose as carbon sources. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base. A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.,Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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