Sandbox k11v

Toxic Amyloid Small Oligomer’s atomic view

spinqualitylabelsall models Structure of alpha-beta crystallin. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D The interactive Molecular Tour below assumes that you are familiar with the journal article PDB'S are K11V (3SGO), K11V-Br2 (3SGM), K11V-Br8 (3SGN), K11VV2L (3SGP), K11V-TR (3SGR), and GDVIEV (3SGS). Introduction Amyloid fibrils were suspected for long to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities.Segment of amyloid forming protein alpha-beta crystallin makes oligomeric complex which exhibits properties of other amyloid oligomers.The structure of oligomer shows a cylindrical barrel,made up of six anti-parallel protein strands known as cylindrin.This segment(coloured in black) termed as K11V forms the cylindrin structure.

References

(1) Laganowsky, A., Liu, C., Sawaya, M. R., Whitelegge, J. P., Park, J., Zhao, M., Pensalfini, A., Soriaga, A. B., Landau, M., Teng, P. K., Cascio, D., Glabe, C. & Eisenberg, D. (2012) Atomic view of a toxic amyloid small oligomer, Science. 335, 1228-31.